HPE accelerates enterprise AI innovation with next-generation AMD CPU-powered servers

• 13 Oct 2026
• TM Team
• 0 Comments

HPE announced the first four of its HPE ProLiant Gen13 Servers powered by 6th Generation AMD EPYC™ Server processors. The new systems expand compute, memory, and I/O capabilities to help enterprises accelerate agentic AI and inference, analytics, virtualisation, simulation, and modeling while strengthening security, simplifying operations, and providing reliability across distributed IT environments.

As AI systems evolve from generating insights to taking autonomous action, trust becomes a prerequisite for scale. McKinsey’s 2026 AI Trust Maturity Survey found that nearly two-thirds of respondents cited security and risk concerns as the top barrier to fully scaling agentic AI.[1] Within this evolving landscape, HPE ProLiant Gen13 helps customers address security and operational barriers with a trusted infrastructure foundation that combines HPE iLO 8 innovations for automatic protection, infrastructure trust, and post-quantum readiness with enhanced visibility and control from HPE Compute Ops Management. 

“Organisations need to turn their investments in agentic AI and inference into business value without adding operational complexity or risk,” said Krista Satterthwaite, senior vice president and general manager, Compute at HPE. “For these workloads, HPE ProLiant Gen13 brings together optimised performance, built-in, automatic security, intelligent operations, and proven reliability. It gives customers a trusted foundation to modernise and innovate today and adapt as their requirements evolve.”

“AI is moving into the applications and operations that run the enterprise, fundamentally changing what organisations demand from their infrastructure,” said Dan McNamara, senior vice president and general manager, Compute and Enterprise AI, AMD. “Across generations of AMD EPYC CPUs and HPE ProLiant servers, our teams have worked side by side to turn advances in processor and system design into practical value for customers. With 6th Gen AMD EPYC processors and HPE ProLiant Gen13, we are delivering the performance, efficiency and flexibility enterprises need to scale AI while modernising the critical workloads their businesses depend on.”